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Friday, March 24 • 1:50pm - 2:35pm
Update: Immune Related Adverse Events From Cancer Immunotherapy

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The introduction of new immunotherapies for cancer have been described as one of the greatest advances in modern medicine over the past 5 years.  These therapies which exploit so called ‘immunologic check points’ release inherent brakes on adaptive immunity allowing for relatively specific and effective anti-tumoral responses.  These therapies are now clinically available in the community and being used for an increasing spectrum of malignancies including melanoma, non-small cell lung cancer, uroepithelial cancers and others.  Many additional drugs are currently in trial and will be likely to be seen in the near future.  Attendant to these therapies are a remarkable array of adverse events secondary to immune activation with varying degrees of target organ specificity. Most commonly these immune related adverse events (irAEs) involve skin, bowel, liver, lung endocrine organs as well as others.  Patients with pre-existing immunologic disease appear vulnerable.  Prompt recognition and therapy generally with glucocorticoids and even at times a second biologic are often required. It is imperative that physicians caring for immunologic disease become familiar with these irAEs and develop strategies to diagnose and manage with their oncologic colleagues. 

  • Describe the MOA of check point therapy for cancer and relate the emergence of irAEs as a bye product
  • Recognize and diagnose common irAEs as seen with currently available agents
  • Craft and apply rationale immunotherapy for the range of irAEs and work interprofessionally with oncologists to optimize therapy for cancer 

avatar for Leonard H. Calabrese, DO

Leonard H. Calabrese, DO

Professor of Medicine Cleveland Clinic Lerner College of Medicine Case Western Reserve University R.J. Fasenmyer Chair of Clinical Immunology Theodore F. Classen, DO Chair of Osteopathic Research and Education Vice Chairman, Department of Rheumatic and Immunologic Diseases

Friday March 24, 2017 1:50pm - 2:35pm