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Friday, March 24 • 2:35pm - 3:35pm
Changing the Treatment Paradigm by Inhibiting Key Intracellular Pathways: A 3D View of Targeted Therapy for the Patient with Rheumatoid Arthritis

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Scientific breakthroughs over the past decade have led to a broader understanding of the pathophysiology of RA that have resulted in tremendous advances in treatment options such as conventional DMARDs, biological DMARDs and oral, small moleculeinhibitors of intracellular pathways . The revelation that numerous proinflammatory cytokines use the Janus Kinase (JAK) intracellular pathway for signal transduction has informed the development of JAK-inhibitors. This session will provide an understanding of the intracellular processes involved in cytokine signaling that results in the inflammation and tissue destruction found in RA and provides a foundation for optimizing the use of these agents. The evolution of treatment strategies, recommendations, and trial design to a focus on tight control using composite measures of disease activity and health-related quality of life with appropriate switching of agents to achieve and maintain patient function and disease remission will be explored. Lastly, tools to incorporate the patient perspective, improve adherence, and aid in the  long-term management of RA will be discussed.

  • Describe the intracellular pathways underlying inflammatory pathology in rheumatoid arthritis
  • Review the interactions between proinflammatory cytokines and the Janus kinase signaling pathway in rheumatoid arthritis
  • Discuss available and emerging JAK inhibitor clinical trial data supporting their use in the management of patients with rheumatoid arthritis

avatar for Maria Greenwald, MD, FACR

Maria Greenwald, MD, FACR

Director, Desert Medical Advances
avatar for Gregg J. Silverman, MD

Gregg J. Silverman, MD

Professor of Medicine and Pathology, NYU School of Medicine, Alexandria Center for Life Science

Friday March 24, 2017 2:35pm - 3:35pm